[Decrease in the immunoreactivity of protein 7B2 in vasopressinergic cells in the supraoptic nucleus and in fibers of the neurohypophysis, in Brattleboro rats].

Immunoreactivity to the secretory protein 7B2 (IR-7B2) colocalizes with both AVP and Om in separate groups of neurons in the supraoptic nucleus. In mutant Brattleboro rats, which have aberrant AVP, which results in diabetes insipidus, 7B2 appears to be markedly decreased in vasopressinergic neurons and absent in their corresponding neurohypophyseal terminals. In contrast, no dramatic differences could be observed in oxytonergic somatas and fibers.