Tropical medicine & international health : TM & IH · 2014
Accuracy of cerebrospinal leucocyte count, protein and culture for the diagnosis of acute bacterial meningitis: a comparative study using Bayesian latent class analysis.
Сравнительное исследованиеСтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Manning Laurens, Laman Moses, Mare Trevor, Hwaiwhanje Ilomo, Siba Peter, Davis Timothy M E
Аннотация
OBJECTIVE: To examine the utility of laboratory methods other than bacterial culture in diagnosing acute bacterial meningitis (ABM).
METHODS: Bayesian latent class analysis was used to estimate diagnostic precision of cerebrospinal fluid (CSF) culture, leucocyte counts and protein concentrations for ABM in Melanesian children.
RESULTS: With a cut-off of ≥20 leucocytes/mm(3) , the area under the receiver operating characteristic curve (AUC ROC) was >97.5% for leucocyte counts. A lower (93%) AUC ROC was observed for CSF protein concentrations ≥1 g/l. CSF culture had poor sensitivity and high specificity.
CONCLUSION: Leucocyte counts provide sufficient diagnostic precision to aid clinical decision-making in ABM.
METHODS: Bayesian latent class analysis was used to estimate diagnostic precision of cerebrospinal fluid (CSF) culture, leucocyte counts and protein concentrations for ABM in Melanesian children.
RESULTS: With a cut-off of ≥20 leucocytes/mm(3) , the area under the receiver operating characteristic curve (AUC ROC) was >97.5% for leucocyte counts. A lower (93%) AUC ROC was observed for CSF protein concentrations ≥1 g/l. CSF culture had poor sensitivity and high specificity.
CONCLUSION: Leucocyte counts provide sufficient diagnostic precision to aid clinical decision-making in ABM.