Frontiers in allergy · 2026
Effects of body mass index on the distributions, severity and surgical outcomes of chronic rhinosinusitis subtypes: a longitudinal study.
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Yang Feng-Ling, Wang Biao, Jiang Zhen-Hua, Xia Li, Deng Wei, Zhang Li-Jun, Li Shu-Hua, Cai Yan, Li Xiao-Xiang
Аннотация
OBJECTIVE: Metabolic disorders significantly affect patients' physical health in various ways, yet their effects on different subtypes of chronic rhinosinusitis remain unclear. This study aimed to investigate how overweight and obesity affect the distributions, severity, and surgical outcomes of various chronic rhinosinusitis subtypes.
METHODS: Through a retrospective longitudinal analysis of the clinical data of 688 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery in a tertiary hospital, the effects of BMI on chronic rhinosinusitis were evaluated.
RESULTS: The study found that the proportion of fungal sinusitis was lower in overweight or obese patients (P = 0.041). Patients who were overweight or obese had higher preoperative CT Lund‒Mackay scores (P = 0.005), and a similar trend was observed in those with neutrophil-infiltrated chronic rhinosinusitis (P = 0.035). By employing a propensity score weighted mixed effect model, the endoscopic scores of chronic rhinosinusitis patients who were overweight or obese were consistently higher than those of patients without these conditions at 1, 3, and 6 months after endoscopic sinus surgery (P < 0.001). This trend was observed both in patients with chronic rhinosinusitis with polyps and without polyps and in patients with eosinophil-infiltrated and neutrophil-infiltrated chronic rhinosinusitis.
CONCLUSION: Overweight and obesity affect the distributions, severity, and surgical outcomes of different chronic rhinosinusitis subtypes. Therefore, the impact of BMI should also be considered when managing chronic rhinosinusitis.
METHODS: Through a retrospective longitudinal analysis of the clinical data of 688 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery in a tertiary hospital, the effects of BMI on chronic rhinosinusitis were evaluated.
RESULTS: The study found that the proportion of fungal sinusitis was lower in overweight or obese patients (P = 0.041). Patients who were overweight or obese had higher preoperative CT Lund‒Mackay scores (P = 0.005), and a similar trend was observed in those with neutrophil-infiltrated chronic rhinosinusitis (P = 0.035). By employing a propensity score weighted mixed effect model, the endoscopic scores of chronic rhinosinusitis patients who were overweight or obese were consistently higher than those of patients without these conditions at 1, 3, and 6 months after endoscopic sinus surgery (P < 0.001). This trend was observed both in patients with chronic rhinosinusitis with polyps and without polyps and in patients with eosinophil-infiltrated and neutrophil-infiltrated chronic rhinosinusitis.
CONCLUSION: Overweight and obesity affect the distributions, severity, and surgical outcomes of different chronic rhinosinusitis subtypes. Therefore, the impact of BMI should also be considered when managing chronic rhinosinusitis.