Bowel movement alterations predict the severity of diverticular disease and the risk of acute diverticulitis: a prospective, international study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tursi Antonio, Piovani Daniele, Brandimarte Giovanni, Di Mario Francesco, Elisei Walter, Picchio Marcello, Figlioli Gisella, Bassotti Gabrio, Allegretta Leonardo, Annunziata Maria Laura, Bafutto Mauro, Bianco Maria Antonia, Colucci Raffaele, Conigliaro Rita, Dumitrascu Dan L, Escalante Ricardo, Ferrini Luciano, Forti Giacomo, Franceschi Marilisa, Graziani Maria Giovanna, Lammert Frank, Latella Giovanni, Lisi Daniele, Maconi Giovanni, Compare Debora, Nardone Gerardo, Camara de Castro Oliveira Lucia, Enio Chaves Oliveira, Papagrigoriadis Savvas, Pietrzak Anna, Pontone Stefano, Stundiene Ieva, Poškus Tomas, Pranzo Giuseppe, Reichert Matthias Christian, Rodino Stefano, Regula Jaroslaw, Scaccianoce Giuseppe, Scaldaferri Franco, Vassallo Roberto, Zampaletta Costantino, Zullo Angelo, Spaziani Erasmo, Bonovas Stefanos, Papa Alfredo, Danese Silvio, DICA International Group
Аннотация
METHODS: An international, multicenter, prospective cohort study was conducted in 43 centers. A 10-point visual analog scale (VAS) was used to assess the severity of constipation and diarrhea. The association of constipation and diarrhea with DICA classification, CODA score, and basal FC was tested using non-parametric tests. Survival methods for censored observations were applied to test the association of constipation and diarrhea with the incidence of acute diverticulitis over a 3-year follow-up.
RESULTS: Of 871 patients with DD were included in the study. Of these, 208 (23.9%) and 199 (22.9%) reported a VAS score for constipation and diarrhea at least 3 at baseline, respectively. Higher constipation and diarrhea scores were associated with increasing DICA classification, CODA score and basal FC (P< 0.001). Constipation and diarrhea scores were independently associated with an increased hazard of developing acute diverticulitis (hazard ratio [HR]constipation = 1.15 per 1-VAS point increase, 95% confidence interval [CI], 1.04-1.27; P=0.004; and HRdiarrhea =1.14; 95% CI, 1.03-1.26; P=0.014, respectively).
CONCLUSIONS: In newly diagnosed patients with DD, higher endoscopic and combined scores of DD severity were associated with higher scores of constipation and diarrhea at baseline. Both constipation and diarrhea were independent prognostic factors of acute diverticulitis.