Head & neck · 2026
Outcomes Following en Bloc Resection of Olfactory Neuroblastoma.
СтатьяНазвание и аннотация: Перевод в очереди
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Omura Kazuhiro, Terazawa Kosuke, Nomura Kazuhiro, Aoki Satoshi, Takeda Teppei, Ebihara Teru, Otori Nobuyoshi
Аннотация
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the nasal olfactory sensory epithelium. It accounts for 3%-5% of all sinonasal malignancies.
METHODS: We evaluated patients with ONB who underwent en bloc resection using an endoscopic endonasal transcribriform approach.
RESULTS: This study included 65 patients. The median follow-up period was 30.6 months. The 2- and 5-year overall survival (OS) rates were both 96.7%, the 2- and 5-year disease-specific survival (DSS) rates were both 98.3%, and the 2- and 5-year disease-free survival (DFS) rates were 81.7% and 59.1%, respectively.
CONCLUSION: OS and DFS of en bloc resection were comparable to those reported in previous studies, with minimal operation-related complications. Recurrence can occur even in patients with low Kadish and Hyams grades, making it unclear which patients would benefit most from postoperative radiation therapy.
METHODS: We evaluated patients with ONB who underwent en bloc resection using an endoscopic endonasal transcribriform approach.
RESULTS: This study included 65 patients. The median follow-up period was 30.6 months. The 2- and 5-year overall survival (OS) rates were both 96.7%, the 2- and 5-year disease-specific survival (DSS) rates were both 98.3%, and the 2- and 5-year disease-free survival (DFS) rates were 81.7% and 59.1%, respectively.
CONCLUSION: OS and DFS of en bloc resection were comparable to those reported in previous studies, with minimal operation-related complications. Recurrence can occur even in patients with low Kadish and Hyams grades, making it unclear which patients would benefit most from postoperative radiation therapy.