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DOI 10.1038/s41593-023-01359-8

Медицинская библиотека · Nature neuroscience · 2023

Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).

McKay Nicole S, Gordon Brian A, Hornbeck Russ C, Dincer Aylin, Flores Shaney, Keefe Sarah J, Joseph-Mathurin Nelly, Jack Clifford R, Koeppe Robert, Millar Peter R, Ances Beau M, Chen Charles D, Daniels Alisha, Hobbs Diana A, Jackson Kelley, Koudelis Deborah, Massoumzadeh Parinaz, McCullough Austin, Nickels Michael L, Rahmani Farzaneh, Swisher Laura, Wang Qing, Allegri Ricardo F, Berman Sarah B, Brickman Adam M, Brooks William S, Cash David M, Chhatwal Jasmeer P, Day Gregory S, Farlow Martin R, la Fougère Christian, Fox Nick C, Fulham Michael, Ghetti Bernardino, Graff-Radford Neill, Ikeuchi Takeshi, Klunk William, Lee Jae-Hong, Levin Johannes, Martins Ralph, Masters Colin L, McConathy Jonathan, Mori Hiroshi, Noble James M, Reischl Gerald, Rowe Christopher, Salloway Stephen, Sanchez-Valle Raquel, Schofield Peter R, Shimada Hiroyuki, Shoji Mikio, Su Yi, Suzuki Kazushi, Vöglein Jonathan, Yakushev Igor, Cruchaga Carlos, Hassenstab Jason, Karch Celeste, McDade Eric, Perrin Richard J, Xiong Chengjie, Morris John C, Bateman Randall J, Benzinger Tammie L S, Dominantly Inherited Alzheimer Network

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in three genes. Offspring from ADAD families have a 50% chance of inheriting their familial mutation, so non-carrier siblings can be recruited for comparisons in case-control studies. The age of onset in ADAD is highly predictable within families, allowing researchers to estimate an individual's point in the disease trajectory. These characteristics allow candidate AD biomarker measurements to be reliably mapped during the preclinical phase. Although ADAD represents a small proportion of AD cases, understanding neuroimaging-based changes that occur during the preclinical period may provide insight into early disease stages of 'sporadic' AD also. Additionally, this study provides rich data for research in healthy aging through inclusion of the non-carrier controls. Here we introduce the neuroimaging dataset collected and describe how this resource can be used by a range of researchers.

Для цитирования: McKay Nicole S, Gordon Brian A, Hornbeck Russ C, Dincer Aylin, Flores Shaney, Keefe Sarah J, Joseph-Mathurin Nelly, Jack Clifford R, Koeppe Robert, Millar Peter R, Ances Beau M, Chen Charles D, Daniels Alisha, Hobbs Diana A, Jackson Kelley, Koudelis Deborah, Massoumzadeh Parinaz, McCullough Austin, Nickels Michael L, Rahmani Farzaneh, Swisher Laura, Wang Qing, Allegri Ricardo F, Berman Sarah B, Brickman Adam M, Brooks William S, Cash David M, Chhatwal Jasmeer P, Day Gregory S, Farlow Martin R, la Fougère Christian, Fox Nick C, Fulham Michael, Ghetti Bernardino, Graff-Radford Neill, Ikeuchi Takeshi, Klunk William, Lee Jae-Hong, Levin Johannes, Martins Ralph, Masters Colin L, McConathy Jonathan, Mori Hiroshi, Noble James M, Reischl Gerald, Rowe Christopher, Salloway Stephen, Sanchez-Valle Raquel, Schofield Peter R, Shimada Hiroyuki, Shoji Mikio, Su Yi, Suzuki Kazushi, Vöglein Jonathan, Yakushev Igor, Cruchaga Carlos, Hassenstab Jason, Karch Celeste, McDade Eric, Perrin Richard J, Xiong Chengjie, Morris John C, Bateman Randall J, Benzinger Tammie L S, Dominantly Inherited Alzheimer Network. Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).. Nature neuroscience. 2023. DOI: 10.1038/s41593-023-01359-8.

Предметные рубрики MeSH

HumansAlzheimer DiseasePositron-Emission TomographyMagnetic Resonance ImagingNeuroimagingArthrogryposisMutationAmyloid beta-Peptides
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