Hemodynamic effects of verapamil in left ventricular valvular volume overload.

The hemodynamic consequences of aortic and mitral insufficiency may be influenced by the high systemic vascular resistance often seen in these patients. Since the calcium antagonists have been shown to reduce systemic vascular resistance, we evaluated the effects of intravenous verapamil in 23 patients. In 11 patients with aortic insufficiency, verapamil resulted in a 20% increase in cardiac index (p less than 0.001), 18% increase in forward stroke volume index (p less than 0.001), and a 24% decrease in regurgitant fraction (p less than 0.005). In the 12 patients with mitral insufficiency, verapamil resulted in a 19% increase in both cardiac index (p = 0.004), and forward stroke volume index (p less than 0.001), while there was a 19% decrease in regurgitant fraction (p less than 0.02). Left ventricular end-systolic stress decreased significantly in both groups as did end-diastolic stress in the mitral insufficiency group. There was no significant change in several measures of contractile performance, though the end-systolic stress-to-volume index ratio fell significantly (p less than 0.04) in the mitral insufficiency group. Our findings suggest that the vasodilatory effects of intravenous verapamil predominate over the negative inotropic effects in patients with aortic and mitral insufficiency. Verapamil may be of use in patients intolerant to other vasodilators, patients with concomitant ischemic heart disease, or those with supraventricular arrhythmias.