Thrombosis research · 2026
Risk of venous thromboembolism in first-degree relatives of affected patients compared with general population.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Robin Sara, Nau Alice, Laouenan Eloïse, Espinasse Benjamin, Munsch Gaëlle, Le Moigne Emmanuelle, Tromeur Cécile, de Moreuil Claire, Guegan Marie, Melac Solen, Kearon Clive, Douketis James D, Lacut Karine, Delluc Aurélien, Couturaud Francis
Аннотация
BACKGROUND: Determining venous thromboembolism (VTE) risk among first-degree relatives (FDRs) of VTE patients requires effective risk assessment. We aimed to evaluate VTE risk in FDRs of index cases (ICs) compared to the general population.
METHODS: A cross-sectional family study (France, Canada) and a population-based study in the Brest district (France) were conducted. VTEs were adjudicated by an independent clinical event committee. The standardised incidence ratio (SIR), defined as observed-to-expected ratios of VTE in FDR, and 95% confidence interval (CI) were calculated using an indirect standardisation. Expected numbers of VTE were calculated from age-specific incidence rates in the reference population.
RESULTS: Among the 2617 FDRs of 507 ICs with VTE, 123 had VTE (annual incidence: 1.2 per 1000 person-years). Of 367,911 Brest district inhabitants, 576 had VTE (annual incidence: 1.6 per 1000 person-years). Compared with the general population, FDRs had a higher VTE risk when the ICs had unprovoked VTE (SIR 1.31, 95%CI 1.11-1.53), had VTE before 47 years (SIR 3.28, 95%CI 2.69-3.85) or when ≥2 FDRs were affected (SIR 1.51, 95%CI 1.14-1.88). The highest VTE risk in FDRs was observed when ICs had unprovoked VTE and ≥2 affected FDRs (SIR 6.36, 95%CI 5.52-7.20) or when ICs had VTE before 47 and ≥2 affected FDRs (SIR 9.93, 95%CI 7.75-12.12). Factor V Leiden and G20210 prothrombin variant status of ICs had a modest influence.
CONCLUSION: FDR VTE risk is significantly higher when the IC had unprovoked VTE, before 47 years, and/or when multiple FDRs were affected, compared to the general population.
METHODS: A cross-sectional family study (France, Canada) and a population-based study in the Brest district (France) were conducted. VTEs were adjudicated by an independent clinical event committee. The standardised incidence ratio (SIR), defined as observed-to-expected ratios of VTE in FDR, and 95% confidence interval (CI) were calculated using an indirect standardisation. Expected numbers of VTE were calculated from age-specific incidence rates in the reference population.
RESULTS: Among the 2617 FDRs of 507 ICs with VTE, 123 had VTE (annual incidence: 1.2 per 1000 person-years). Of 367,911 Brest district inhabitants, 576 had VTE (annual incidence: 1.6 per 1000 person-years). Compared with the general population, FDRs had a higher VTE risk when the ICs had unprovoked VTE (SIR 1.31, 95%CI 1.11-1.53), had VTE before 47 years (SIR 3.28, 95%CI 2.69-3.85) or when ≥2 FDRs were affected (SIR 1.51, 95%CI 1.14-1.88). The highest VTE risk in FDRs was observed when ICs had unprovoked VTE and ≥2 affected FDRs (SIR 6.36, 95%CI 5.52-7.20) or when ICs had VTE before 47 and ≥2 affected FDRs (SIR 9.93, 95%CI 7.75-12.12). Factor V Leiden and G20210 prothrombin variant status of ICs had a modest influence.
CONCLUSION: FDR VTE risk is significantly higher when the IC had unprovoked VTE, before 47 years, and/or when multiple FDRs were affected, compared to the general population.