Muscle & nerve · 2015
Metabolic syndrome in patients with myotonic dystrophy type 1.
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Vujnic Milorad, Peric Stojan, Popovic Srdjan, Raseta Nela, Ralic Vesna, Dobricic Valerija, Novakovic Ivana, Rakocevic-Stojanovic Vidosava
Аннотация
INTRODUCTION: The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1).
METHODS: We studied 66 DM1 patients (50% men, aged 41.9 ± 10.5 years, disease duration of 19.3 ± 8.6 years). New worldwide consensus criteria for MetS from 2009 were used.
RESULTS: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P > 0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P < 0.05).
CONCLUSION: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.
METHODS: We studied 66 DM1 patients (50% men, aged 41.9 ± 10.5 years, disease duration of 19.3 ± 8.6 years). New worldwide consensus criteria for MetS from 2009 were used.
RESULTS: Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P > 0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P < 0.05).
CONCLUSION: Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.