[Perilesional changes in gastric ulcer].

UNLABELLED: Our work aims to provide a descriptive analysis of the perilesional changes associated with gastric ulcer, which were observed on a group of patients diagnosed by endobiopsy.

MATERIAL AND METHOD: The group comprised 90 persons with clinical diagnosis of gastric ulcer, who were investigated both endoscopically and pathologically. The gastric fragments were processed for light microscopy (HE, PAS, alcian blue stains).

RESULTS

Besides the typical gastric ulcer, the morphological exam identified gastric ulcer combined with chronic gastritis, complete and incomplete intestinal metaplasia, gastric atrophy, hyperplasia as well as dysplasia. A malignant gastric ulcer was confirmed in 6 cases. A number of 10 patients displayed malignant lesions (gastric carcinoma, intestinal and diffuse types) developed independently of the gastric ulcer.

CONCLUSIONS

The identification of various morphological changes in the gastric mucosa adjacent to the ulcer allows a correct evaluation, with respect to the diagnosis and the evolution. The presence of these lesions, correlated with the existence of Helicobacter pylori, means major risk factors for gastric carcinogenesis.