Head & neck · 2026
Malignant Transformation of Oral Epithelial Dysplasia in Southern Finland.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Leino Katariina, Laine Hanna K, Kinnula Ville, Rautava Jaana
Аннотация
BACKGROUND: Oral epithelial dysplasia (OED) often precedes oral squamous cell carcinoma (OSCC). The aim was to elucidate the risk and time of malignant transformation (MT) of OED.
METHODS: Patients diagnosed with OED between 2001 and 2011 in Helsinki and Uusimaa, Finland were included. Kaplan-Meier and Cox proportional hazard analysis factors associated with the MT time.
RESULTS: Dysplasias of 225 patients (mean age 60.0 years, 51.6% females) were diagnosed as mild (85.8%), moderate (11.6%), or severe (2.7%). MT occurred in 14.7% (51.5% females, 48.5% males) at a median time of 5.5 years (IQR 1.7-12.5 years). MT occurred in 33.3% of severe (n = 6), 34.6% (n = 26) of moderate, and 11.4% (n = 193) of mild dysplasia. Dysplasia severity was associated with an increased risk for MT.
CONCLUSIONS: MT of OED was 14.7%. The severity of OED is a predictor for MT.
METHODS: Patients diagnosed with OED between 2001 and 2011 in Helsinki and Uusimaa, Finland were included. Kaplan-Meier and Cox proportional hazard analysis factors associated with the MT time.
RESULTS: Dysplasias of 225 patients (mean age 60.0 years, 51.6% females) were diagnosed as mild (85.8%), moderate (11.6%), or severe (2.7%). MT occurred in 14.7% (51.5% females, 48.5% males) at a median time of 5.5 years (IQR 1.7-12.5 years). MT occurred in 33.3% of severe (n = 6), 34.6% (n = 26) of moderate, and 11.4% (n = 193) of mild dysplasia. Dysplasia severity was associated with an increased risk for MT.
CONCLUSIONS: MT of OED was 14.7%. The severity of OED is a predictor for MT.