European journal of clinical and experimental medicine · 2021
Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome.
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Rahamon Sheu Kadiri, Arinola Olatunbosun Ganiyu, Charles-Davies Mabel Ayebatonyo, Akinlade Kehinde Sola, Olaniyi John Ayodele, Fasanmade Adesoji Adedipe, Oyewole Oyediran Emmanuel, Owolabi Mayowa Ojo, Adebusuyi Jane Roli, Hassan Olufunke Olayemi, Ajobo Muhammed Babatunde, Adigun Kehinde, Ebesunun Maria Onomaghuan, Popoola Omolara Olutosin, Omiyale Wemimo, Agbedana Emmanuel Oluyemi
Аннотация
INTRODUCTION: Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking.
AIM: To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS.
MATERIAL AND METHODS: Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status.
RESULTS: None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS.
CONCLUSION: Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
AIM: To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS.
MATERIAL AND METHODS: Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status.
RESULTS: None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS.
CONCLUSION: Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.