Magma (New York, N.Y.) · 2026
Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.
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Langley Jason, Solis Kitzia, Masjedizadeh Vala, Shao Murphy, Bennett Ilana J, Hu Xiaoping P
Аннотация
OBJECTIVE: Elevated kurtosis values have been observed in subcortical grey matter structures of patients with neurodegenerative diseases. Here, we examined relationships between iron measures and kurtosis in iron-rich subcortical grey matter structures.
MATERIALS AND METHODS: Multi-shell diffusion and multi-echo gradient echo acquisitions were used to derive mean kurtosis and iron measures (R2* and magnetic susceptibility), respectively, in subcortical grey matter nuclei and white matter tracts in a discovery cohort (110 healthy older and 63 younger adults) and replication cohort (72 healthy older adults).
RESULTS: Iron-rich grey matter regions exhibited higher mean kurtosis, R2*, and magnetic susceptibility and white matter regions had lower mean kurtosis in the older adult group from the discovery cohort. In both cohorts, mean kurtosis was significantly correlated with R2* and magnetic susceptibility in iron-rich grey matter nuclei. No association was seen between signal-to-noise ratio and mean kurtosis in any grey matter region, indicating that the increase in mean kurtosis was not due to reduced signal-to-noise.
CONCLUSION: Our findings indicate that kurtosis is associated with iron-sensitive metrics in iron-rich grey matter structures, suggesting that iron deposits may be contributing to kurtosis.
MATERIALS AND METHODS: Multi-shell diffusion and multi-echo gradient echo acquisitions were used to derive mean kurtosis and iron measures (R2* and magnetic susceptibility), respectively, in subcortical grey matter nuclei and white matter tracts in a discovery cohort (110 healthy older and 63 younger adults) and replication cohort (72 healthy older adults).
RESULTS: Iron-rich grey matter regions exhibited higher mean kurtosis, R2*, and magnetic susceptibility and white matter regions had lower mean kurtosis in the older adult group from the discovery cohort. In both cohorts, mean kurtosis was significantly correlated with R2* and magnetic susceptibility in iron-rich grey matter nuclei. No association was seen between signal-to-noise ratio and mean kurtosis in any grey matter region, indicating that the increase in mean kurtosis was not due to reduced signal-to-noise.
CONCLUSION: Our findings indicate that kurtosis is associated with iron-sensitive metrics in iron-rich grey matter structures, suggesting that iron deposits may be contributing to kurtosis.