Journal of glaucoma · 2026
Ocular Biometric Determinants of Intraocular Pressure and Risk Factors for Ocular Hypertension: The Chinese American Eye Study.
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Rajagopalan Archeta, Pardeshi Anmol, Apolo Galo, Burkemper Bruce, Jiang Xuejuan, McKean-Cowdin Roberta, Torres Mina, Varma Rohit, Xu Benjamin Y
Аннотация
PRCIS: Angle width and iris area measured by anterior OCT are increasingly predictive of intraocular pressure and ocular hypertension below parameter-specific angle width cutoffs. Cumulative gonioscopy score is weakly predictive below all score cutoffs.
PURPOSE: To assess ocular biometric determinants of intraocular pressure (IOP) and risk factors for ocular hypertension (OHTN).
METHODS: CHES participants underwent Goldmann applanation tonometry, gonioscopy, ultrasound A-scan, and anterior segment OCT (AS-OCT) imaging. Biometric data from one eye per participant were used to develop linear and logistic regression models of IOP and OHTN (IOP >21 mm Hg), respectively, below different angle width cutoffs adjusted for central cornea thickness (CCT).
RESULTS: A total of 2360 eyes of 2360 eligible participants (1518 female, 842 male) were analyzed. Mean age was 60.2±7.8 years. Multivariable stepwise linear regression models and change-point analysis showed that below a trabecular iris space area (TISA 750 ) measurement of 0.08 mm 2 , models became increasingly predictive of IOP up to an adjusted R 2 of 0.84. Smaller TISA 750 and iris area (IA) were the only parameters consistently associated ( P ≤0.04) with higher IOP for TISA 750 below 0.20, 0.10, and 0.05 mm 2 . In multivariable models of OHTN (AUC≤0.95), smaller TISA 750 was associated with OHTN for TISA 750 <0.20, 0.10, and 0.05 mm 2 ( P ≤0.03), while IA was associated with OHTN for TISA 750 <0.05 mm 2 ( P ≤0.03). Cumulative gonioscopy score (sum of gonioscopy grades) was weakly predictive of IOP at all cutoffs (adjusted R 2 ≤0.08).
CONCLUSION: TISA 750 and IA become strongly predictive of IOP when angle width decreases below a TISA 750 cutoff of 0.08 mm 2 . The relationship between cumulative gonioscopy score and IOP is weak below all gonioscopy score cutoffs. AS-OCT measurements could supplement gonioscopy by helping identify individuals at higher risk for elevated IOP from angle closure.
PURPOSE: To assess ocular biometric determinants of intraocular pressure (IOP) and risk factors for ocular hypertension (OHTN).
METHODS: CHES participants underwent Goldmann applanation tonometry, gonioscopy, ultrasound A-scan, and anterior segment OCT (AS-OCT) imaging. Biometric data from one eye per participant were used to develop linear and logistic regression models of IOP and OHTN (IOP >21 mm Hg), respectively, below different angle width cutoffs adjusted for central cornea thickness (CCT).
RESULTS: A total of 2360 eyes of 2360 eligible participants (1518 female, 842 male) were analyzed. Mean age was 60.2±7.8 years. Multivariable stepwise linear regression models and change-point analysis showed that below a trabecular iris space area (TISA 750 ) measurement of 0.08 mm 2 , models became increasingly predictive of IOP up to an adjusted R 2 of 0.84. Smaller TISA 750 and iris area (IA) were the only parameters consistently associated ( P ≤0.04) with higher IOP for TISA 750 below 0.20, 0.10, and 0.05 mm 2 . In multivariable models of OHTN (AUC≤0.95), smaller TISA 750 was associated with OHTN for TISA 750 <0.20, 0.10, and 0.05 mm 2 ( P ≤0.03), while IA was associated with OHTN for TISA 750 <0.05 mm 2 ( P ≤0.03). Cumulative gonioscopy score (sum of gonioscopy grades) was weakly predictive of IOP at all cutoffs (adjusted R 2 ≤0.08).
CONCLUSION: TISA 750 and IA become strongly predictive of IOP when angle width decreases below a TISA 750 cutoff of 0.08 mm 2 . The relationship between cumulative gonioscopy score and IOP is weak below all gonioscopy score cutoffs. AS-OCT measurements could supplement gonioscopy by helping identify individuals at higher risk for elevated IOP from angle closure.