Archives of medical science : AMS · 2025
Increased blood urea nitrogen to serum albumin ratio is associated with poor prognosis in patients with acute pancreatitis: a retrospective cohort study.
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Huang Yun, Zhang Chunyan, Li Meiqiu, Mei Jun, Wu Yingxin, Xiang Xia
Аннотация
INTRODUCTION: The blood urea nitrogen to serum albumin ratio (BAR) may serve as a prognostic marker. This study evaluated its association with clinical outcomes in patients with acute pancreatitis (AP).
MATERIAL AND METHODS: We performed a retrospective cohort analysis using data from the MIMIC-IV 2.2 database, including 650 patients diagnosed with AP. The primary outcomes were 90-day and 365-day mortality. Cox proportional hazards models assessed the relationship between BAR and mortality. Restricted cubic spline (RCS) analysis examined the non-linear relationship.
RESULTS: Among the 650 patients, the mortality rates at 90 days and 365 days were 21.2% and 26.2%, respectively. Higher BAR levels correlated with increased 90-day and 365-day mortality (p < 0.001). BAR had hazard ratios (HR) of 1.04 (95% CI: 1.02-1.06) for 90-day and 1.04 (95% CI: 1.02-1.05) for 365-day mortality. ROC analysis revealed that BAR's AUC was 0.738 for 90-day and 0.714 for 365-day mortality. Subgroup and sensitivity analyses indicated stable results across various conditions.
CONCLUSIONS: Elevated BAR is significantly associated with increased mortality in AP patients, indicating its potential as a valuable prognostic marker in critical care settings.
MATERIAL AND METHODS: We performed a retrospective cohort analysis using data from the MIMIC-IV 2.2 database, including 650 patients diagnosed with AP. The primary outcomes were 90-day and 365-day mortality. Cox proportional hazards models assessed the relationship between BAR and mortality. Restricted cubic spline (RCS) analysis examined the non-linear relationship.
RESULTS: Among the 650 patients, the mortality rates at 90 days and 365 days were 21.2% and 26.2%, respectively. Higher BAR levels correlated with increased 90-day and 365-day mortality (p < 0.001). BAR had hazard ratios (HR) of 1.04 (95% CI: 1.02-1.06) for 90-day and 1.04 (95% CI: 1.02-1.05) for 365-day mortality. ROC analysis revealed that BAR's AUC was 0.738 for 90-day and 0.714 for 365-day mortality. Subgroup and sensitivity analyses indicated stable results across various conditions.
CONCLUSIONS: Elevated BAR is significantly associated with increased mortality in AP patients, indicating its potential as a valuable prognostic marker in critical care settings.