Medicina intensiva · 2025
Triglyceride-Glucose Index as a predictor of severity in acute pancreatitis: Systematic Review and Meta-Analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Vásquez-Tirado Gustavo Adolfo, Aguirre-Varas Odett Yamile, Meregildo-Rodríguez Edinson Dante, Quispe-Castañeda Claudia Vanessa, Guzmán-Aguilar Wilson Marcial, Liñán-Díaz Leslie Jacqueline, Rodríguez-Chávez Luis Ángel
Аннотация
OBJECTIVE: The triglyceride-glucose (TyG) index has been proposed as a novel predictive variable of severe acute pancreatitis (SAP) DESIGN: Systematic review and meta-analysis.
SETTING: A comprehensive search was conducted across five databases of studies published up to March 17, 2024, using the PECO strategy. Seven studies were identified and included in our meta-analysis.
PARTICIPANTS: The participants of the included primary studies (non-severe acute pancreatitis).
INTERVENTIONS: High triglyceride-glucose (TyG) index MAIN VARIABLES OF INTEREST: Severe acute pancreatitis, RESULTS: Our analysis evaluated the risk of progression to severity in patients with elevated TyG index in acute pancreatitis through four non-randomized studies. The TyG index was found to be a predictor of severity in acute pancreatitis, with an overall severity risk (OR: 2.38; 95% CI: 1.50-4.08; I²: 80%). Additionally, the analysis of the standardized mean difference (SMD) across all seven studies between patients with SAP and non-SAP yielded an overall mean (OR: 0.90; 95% CI: 0.70-1.11; I²: 28%).
CONCLUSION: In patients with acute pancreatitis, a TyG index is a predictor of severity.
SETTING: A comprehensive search was conducted across five databases of studies published up to March 17, 2024, using the PECO strategy. Seven studies were identified and included in our meta-analysis.
PARTICIPANTS: The participants of the included primary studies (non-severe acute pancreatitis).
INTERVENTIONS: High triglyceride-glucose (TyG) index MAIN VARIABLES OF INTEREST: Severe acute pancreatitis, RESULTS: Our analysis evaluated the risk of progression to severity in patients with elevated TyG index in acute pancreatitis through four non-randomized studies. The TyG index was found to be a predictor of severity in acute pancreatitis, with an overall severity risk (OR: 2.38; 95% CI: 1.50-4.08; I²: 80%). Additionally, the analysis of the standardized mean difference (SMD) across all seven studies between patients with SAP and non-SAP yielded an overall mean (OR: 0.90; 95% CI: 0.70-1.11; I²: 28%).
CONCLUSION: In patients with acute pancreatitis, a TyG index is a predictor of severity.