Bioanalysis · 2016
Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood.
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Battista Marie-Claude, Boutin Michel, Venne Philippe, Blais Lucie, Bérard Anick, Lacroix Marilyn, Patenaude Julie, Guillemette Laetitia, Cossette Benoit, Hivert Marie-France, Auray-Blais Christiane
Аннотация
BACKGROUND: Despite recommendations to use inhaled corticosteroids as treatment to control asthma during pregnancy, it is unknown whether inhaled fluticasone propionate (FP) reaches the fetus. Results & methodology: We collected maternal blood on the morning following delivery. FP was detected by ultra-performance LC-MS/MS (UPLC-MS/MS) in 9/17 asthmatic women using FP. Delay between last FP inhalation and maternal blood sampling ranged between 3 and 33 h and FP was detected in a range of 1.572-46.440 pg/ml. Among the nine offspring of these FP users, FP was detected in five cord blood samples. Delay between last predelivery FP inhalation and cord blood sampling ranged from 4 to 20 h and FP was detected in a range of 0.423-4.510 pg/ml.
CONCLUSION: Our findings demonstrate placental passage of inhaled FP.
CONCLUSION: Our findings demonstrate placental passage of inhaled FP.