Internal medicine (Tokyo, Japan) · 2022
Parietal Cell Dysfunction: A Rare Cause of Gastric Neuroendocrine Neoplasm with Achlorhydria and Extreme Hypergastrinemia.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Abe Yasuaki, Hatta Waku, Asonuma Sho, Koike Tomoyuki, Abe Hiroko, Ogata Yohei, Saito Masahiro, Jin Xiaoyi, Kanno Takeshi, Uno Kaname, Asano Naoki, Imatani Akira, Fujishima Fumiyoshi, Sasano Hironobu, Masamune Atsushi
Аннотация
A 69-year-old woman with multiple neuroendocrine neoplasms (NENs) was referred to our hospital. Although she had extreme hypergastrinemia (11,675 pg/mL), no findings that indicated types I to III gastric NENs were found. Although gastric corpus atrophy was suspected on conventional white-light imaging, findings on magnifying endoscopy with narrow-band imaging indicated no severe atrophy. A biopsy from the background fundic gland mucosa revealed no atrophic changes, parietal cells with vacuolated cytoplasm and negative findings for H+K+-ATPase. Thus, this case was diagnosed as multiple NENs with parietal cell dysfunction. Neither progression nor metastasis has been confirmed during two-year follow-up.