Photobiomodulation, photomedicine, and laser surgery · 2026
The Role of Photobiomodulation Therapy in Enhancing Neurogenesis: Mechanisms and Applications.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Wenhao, Deng Qianting, Liu Timon Cheng-Yi, Yang Luodan
Аннотация
BACKGROUND: Adult neurogenesis, critical for neural repair and functional plasticity, is impaired in neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and traumatic brain injury (TBI).
OBJECTIVE: This review summarizes the physiological basis of adult neurogenesis and photobiomodulation (PBM) fundamentals, clarifies PBM-induced neurogenesis mechanisms, evaluates its pre-clinical/clinical efficacy and safety, and addresses translational challenges to support clinical translation.
MATERIALS AND METHODS: We synthesized relevant literature, covering adult neurogenesis characteristics, PBM principles/mechanisms, pre-clinical studies in disorder models, clinical safety/efficacy data, and comparisons with conventional neurogenic therapies.
CONCLUSIONS: PBM promotes neurogenesis via regulating neural stem cell activity, mitochondrial function, and oxidative stress. Pre-clinical/clinical evidence confirms its safety and efficacy; despite parameter and long-term safety challenges, it has great potential in neuroregenerative medicine.
OBJECTIVE: This review summarizes the physiological basis of adult neurogenesis and photobiomodulation (PBM) fundamentals, clarifies PBM-induced neurogenesis mechanisms, evaluates its pre-clinical/clinical efficacy and safety, and addresses translational challenges to support clinical translation.
MATERIALS AND METHODS: We synthesized relevant literature, covering adult neurogenesis characteristics, PBM principles/mechanisms, pre-clinical studies in disorder models, clinical safety/efficacy data, and comparisons with conventional neurogenic therapies.
CONCLUSIONS: PBM promotes neurogenesis via regulating neural stem cell activity, mitochondrial function, and oxidative stress. Pre-clinical/clinical evidence confirms its safety and efficacy; despite parameter and long-term safety challenges, it has great potential in neuroregenerative medicine.