Arquivos de neuro-psiquiatria · 2005
[Diagnostic difficulties in spinal muscular atrophy].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Araújo Alexandra Prufer de Q-C, Ramos Vivianne Galante, Cabello Pedro Hernán
Аннотация
OBJECTIVE: To describe the clinical findings of patients with spinal muscular atrophy (SMA) with survival motor neuron (SMN) gene deletion.
METHOD: Descriptive study of SMA cases confirmed with the deletion of the SMN gene. Frequency determination of positive clinical and laboratory revised diagnostic criteria.
RESULTS: All of the 22 included patients had symmetrical muscle weakness, which was diffuse in those with onset of symptoms up to 6 months of age (75 %), and either proximal or predominant in lower limbs in the remaining group (67 %). Fasciculations and atrophy were both frequent findings (82 %). Laboratory tests findings were variable, with a positivity of 57 % for electrophysiology and of 58 % for muscle biopsy.
CONCLUSION: The presence of a deletion in the SMN gene can help to confirm this diagnosis in unclear presentations.
METHOD: Descriptive study of SMA cases confirmed with the deletion of the SMN gene. Frequency determination of positive clinical and laboratory revised diagnostic criteria.
RESULTS: All of the 22 included patients had symmetrical muscle weakness, which was diffuse in those with onset of symptoms up to 6 months of age (75 %), and either proximal or predominant in lower limbs in the remaining group (67 %). Fasciculations and atrophy were both frequent findings (82 %). Laboratory tests findings were variable, with a positivity of 57 % for electrophysiology and of 58 % for muscle biopsy.
CONCLUSION: The presence of a deletion in the SMN gene can help to confirm this diagnosis in unclear presentations.