Predictive Value of LncRNA TUG1 for Complications after Caesarean Section with Scarred Uterus.

This study aims to investigate the predictive value of long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) for complications following cesarean section in patients with scarred uterus. We first included 186 subjects with scarred uterus. The levels of TUG1 in the serum of these subjects were measured using RT-qPCR, and based on the expression levels of TUG1, they were divided into TUG1 high expression group (90 cases) and TUG1 low expression group (96 cases). The postpartum hemorrhage, postoperative site infections, pelvic floor muscle strength, and vaginal microbiota status were compared between the two groups. And the predictive value of TUG1 for complications following cesarean section in women with scarred uteri was assessed using the receiver operating characteristic (ROC) curve. The levels of TUG1 were found to be strongly positively correlated with the abdominal scar score of the pregnant women. Furthermore, TUG1 levels in women who experienced pelvic floor dysfunction (PFD), vaginal microbiome disorders, surgical site infections (SSI), and postpartum hemorrhage were significantly higher than those in women without these complications. The ROC curve indicated that TUG1 predicted PFD, vaginal microbiota disorders, SSI, and postpartum hemorrhage with areas under the curve (AUC) of 0.811, 0.832, 0.819, and 0.887, respectively. TUG1 was positively correlated with abdominal scar scores and demonstrated good predictive value for complications after cesarean section in women with scarred uteri. These findings suggest that TUG1 has the potential to serve as a clinical biomarker for these complications.