European journal of endocrinology · 2008
The influence of age on the GH-IGF1 axis in patients with acromegaly.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tanimoto Keiji, Hizuka Naomi, Fukuda Izumi, Takano Kazue, Hanafusa Toshiaki
Аннотация
OBJECTIVE: The purpose of this study was to investigate the influence of age on GH and IGF1 axis, and complications in patients with acromegaly.
SUBJECTS AND METHODS: From the medical records, we retrospectively analyzed clinical features and complications in 87 newly diagnosed patients with active acromegaly (34 males, 53 females; aged 18-82 years) who were admitted to Tokyo Women's Medical University between 1999 and 2006. We divided the patients into three groups according to age: <or=30 years old (young group), 31-60 years old (middle-aged group), and >or=61 years old (elderly group).
RESULTS: The median GH levels in young, middle-aged, and elderly groups were 18.5, 8.8, and 6.7 microg/l respectively, and the IGF1 levels were 810, 717, and 740 microg/l respectively. The values were not significantly different among the groups. However, the serum IGF1 SDS were significantly higher in the elderly group (10.2) than those in young and middle-aged groups (6.6 and 6.2 respectively, P<0.001). The age difference in the higher IGF1 SDS was remarkable in female patients. In the elderly group, glucose intolerance and hypertension were found in 94 and 53% of the patients respectively and the incidences were higher than those in the other groups.
CONCLUSION: This study suggests that the relatively high IGF1 secretions in elderly patients might be involved in the progression of clinical complications in acromegalic patients. Therefore, awareness of the early symptoms and examination of serum GH and IGF1 are important for patients with acromegaly.
SUBJECTS AND METHODS: From the medical records, we retrospectively analyzed clinical features and complications in 87 newly diagnosed patients with active acromegaly (34 males, 53 females; aged 18-82 years) who were admitted to Tokyo Women's Medical University between 1999 and 2006. We divided the patients into three groups according to age: <or=30 years old (young group), 31-60 years old (middle-aged group), and >or=61 years old (elderly group).
RESULTS: The median GH levels in young, middle-aged, and elderly groups were 18.5, 8.8, and 6.7 microg/l respectively, and the IGF1 levels were 810, 717, and 740 microg/l respectively. The values were not significantly different among the groups. However, the serum IGF1 SDS were significantly higher in the elderly group (10.2) than those in young and middle-aged groups (6.6 and 6.2 respectively, P<0.001). The age difference in the higher IGF1 SDS was remarkable in female patients. In the elderly group, glucose intolerance and hypertension were found in 94 and 53% of the patients respectively and the incidences were higher than those in the other groups.
CONCLUSION: This study suggests that the relatively high IGF1 secretions in elderly patients might be involved in the progression of clinical complications in acromegalic patients. Therefore, awareness of the early symptoms and examination of serum GH and IGF1 are important for patients with acromegaly.