Technical innovations & patient support in radiation oncology · 2025
Direct-to-treatment MRI-guided prostate radiotherapy using a generic patient-agnostic reference plan.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Tsekas Georgios, Wiersema Lisa, Conijn Sanne, Sundaram Jega, van der Heide Uulke A, Janssen Tomas
Аннотация
BACKGROUND: Background and Purpose: Offline plan preparation is a time-consuming step in MRI-guided radiotherapy (MRIgRT). This work explores the use of a patient-agnostic reference plan and delineations for direct-to-treatment (DtT) MRI-guided prostate RT, without any patient-specific treatment preparations.
MATERIAL AND METHODS: The data of ten prostate cancer patients were used to simulate a (DtT) workflow: During fraction 1, patient-specific contour adaptations were performed and a treatment plan was created, which was used for the rest of the fractions. The DtT treatment plans were evaluated against the clinical RT plans using the clinical delineations.
RESULTS: All DtT plans reached sufficient PTV coverage (V3444cGy > 99%), while resulting in comparable OAR dose distributions to the clinical plans.
CONCLUSION: Our DtT workflow resulted in adequate PTV coverage at the cost of small increase to the dose of some organs-at-risk and a high overall efficiency gain.
MATERIAL AND METHODS: The data of ten prostate cancer patients were used to simulate a (DtT) workflow: During fraction 1, patient-specific contour adaptations were performed and a treatment plan was created, which was used for the rest of the fractions. The DtT treatment plans were evaluated against the clinical RT plans using the clinical delineations.
RESULTS: All DtT plans reached sufficient PTV coverage (V3444cGy > 99%), while resulting in comparable OAR dose distributions to the clinical plans.
CONCLUSION: Our DtT workflow resulted in adequate PTV coverage at the cost of small increase to the dose of some organs-at-risk and a high overall efficiency gain.