American journal of ophthalmology · 2001
Leber hereditary optic neuropathy, progressive visual loss, and multiple-sclerosis-like symptoms.
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Tran M, Bhargava R, MacDonald I M
Аннотация
PURPOSE: To report a case of Leber hereditary optic neuropathy with multiple-sclerosis-like symptoms.
METHODS: Observational case report. A 34-year-old man was found to have Leber hereditary optic neuropathy and a mutation at position 11778 of the mitochondrial genome. The progression of vision loss and onset of weakness in the right leg warranted neuroimaging.
RESULTS: Magnetic resonance imaging documented multiple lesions in the brain and spinal cord.
CONCLUSION: Although rarely reported, progression of optic neuropathy over months has been previously documented in Leber hereditary optic neuropathy. The emergence of multiple sclerosis-like symptoms and signs in our patient may be part of the spectrum of Leber hereditary optic neuropathy or a coincidental occurrence.
METHODS: Observational case report. A 34-year-old man was found to have Leber hereditary optic neuropathy and a mutation at position 11778 of the mitochondrial genome. The progression of vision loss and onset of weakness in the right leg warranted neuroimaging.
RESULTS: Magnetic resonance imaging documented multiple lesions in the brain and spinal cord.
CONCLUSION: Although rarely reported, progression of optic neuropathy over months has been previously documented in Leber hereditary optic neuropathy. The emergence of multiple sclerosis-like symptoms and signs in our patient may be part of the spectrum of Leber hereditary optic neuropathy or a coincidental occurrence.