[Experiences with the intranasal and parenteral use of 1-desamino-8-D-arginine vasopressin (DDAVP)--effect of one time parenteral and intranasal applications].

The balance examinations in 10 patients with a neurohypophyseal diabetes insipidus under various forms of parenteral application (s.c., i.m., i.v.) of the 1-desamino-8-D-arginine-vasopressin show universally the very good antidiuretic effect also under these conditions. Identically with the course of action after intravenous application the maximum of action as obtained after 1 to 2 hours, the duration of action depends on the dosage, in parenteral application of 1 microgram 18 to 24 hours, on an average 20 hours. According to the results demonstrated there are no references to a specific influence of the excretion of sodium, potassium and urea. The particular dynamics of the excretion rates of these substances, of the osmolarity clearance and the osmolarity of the urine is the sequel of the restitution of the renal concentration ability under the application of the antidiuretic hormone.