British journal of neurosurgery · 2026
Subarachnoid haemorrhage in paediatric hereditary haemorrhagic telangiectasia: a case report and literature review.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Elgazar Sarah, Faccenda Alberto, Ghotra Ebaney, Sato Alma, Than Christian A, Elborady Mohamed A, Guilfoyle Mathew R, Rajapakse Dilina, Jalloh Ibrahim
Аннотация
PURPOSE: Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder characterised by telangiectasias and multi-organ arteriovenous malformations (AVMs). Subarachnoid haemorrhage (SAH) is rare in children with HHT, and intracranial aneurysms are scarcely reported. We describe the case of a 12-year-old boy with confirmed HHT who presented with a generalised tonic-clonic seizure, followed by headache and neck pain.
MATERIALS AND METHODS: A narrative literature review was conducted to identify reported paediatric cases of SAH in patients with HHT. MEDLINE, Embase, the Cochrane Library, and CINAHL were searched. Five reports describing six paediatric patients were reviewed and summarised.
RESULTS: Imaging revealed SAH with intraventricular extension. Initial imaging failed to detect any neurovascular malformation, but a small carotid cave aneurysm was identified as the likely haemorrhage source with subsequent digital subtraction angiography. Following treatment with endovascular flow-diverting stent placement, the patient remained neurologically stable. An unrecognised spinal AVM was discovered by whole-spine magnetic resonance imaging.
CONCLUSIONS: This case highlights a rare mechanism of haemorrhage in paediatric HHT, the challenges of detecting small aneurysms with non-invasive imaging, and the importance of a multidisciplinary approach in guiding management. Improved awareness and robust literature on atypical cerebrovascular manifestations may inform future diagnostic and management strategies.
MATERIALS AND METHODS: A narrative literature review was conducted to identify reported paediatric cases of SAH in patients with HHT. MEDLINE, Embase, the Cochrane Library, and CINAHL were searched. Five reports describing six paediatric patients were reviewed and summarised.
RESULTS: Imaging revealed SAH with intraventricular extension. Initial imaging failed to detect any neurovascular malformation, but a small carotid cave aneurysm was identified as the likely haemorrhage source with subsequent digital subtraction angiography. Following treatment with endovascular flow-diverting stent placement, the patient remained neurologically stable. An unrecognised spinal AVM was discovered by whole-spine magnetic resonance imaging.
CONCLUSIONS: This case highlights a rare mechanism of haemorrhage in paediatric HHT, the challenges of detecting small aneurysms with non-invasive imaging, and the importance of a multidisciplinary approach in guiding management. Improved awareness and robust literature on atypical cerebrovascular manifestations may inform future diagnostic and management strategies.