Acta paediatrica (Oslo, Norway : 1992). Supplement · 1996
Preliminary results from follow-up of a large-scale population survey of antibodies to gliadin, reticulin and endomysium.
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Johnston S D, Watson R G, McMillan S A, McMaster D, Evans A
Аннотация
UNLABELLED: Coeliac disease is often under-diagnosed, particularly in cases which are atypical or asymptomatic.
OBJECTIVE: The aim of this study was to comprehensively assess the prevalence and clinical profile of adult coeliac disease in our community.
METHODS: One-hundred-and-thirteen subjects from the most recent MONICA (multinational MONItoring of trends and determinants in CArdiovascular disease)1991/2 survey with positive serology were followed up 3 years after initial screening and assessed by means of (i) a clinical questionnaire, (ii) screening blood tests, and (iii) jejunal biopsy.
RESULTS: Forty-six subjects (21 male, mean age 51 years) have been followed up to date. Prior to follow-up, two of these subjects were diagnosed as having coeliac disease. Ten (3 male, mean age 51 years) of 44 subjects had enteropathy. Three of these 10 subjects were relatively asymptomatic, 3 had folate deficiency and 3 had iron deficiency. Thus 12 of the 1823 initially screened had enteropathy consistent with coeliac disease.
CONCLUSIONS: Coeliac disease is more prevalent than previous estimations and was found to be at least 1 in 152.
OBJECTIVE: The aim of this study was to comprehensively assess the prevalence and clinical profile of adult coeliac disease in our community.
METHODS: One-hundred-and-thirteen subjects from the most recent MONICA (multinational MONItoring of trends and determinants in CArdiovascular disease)1991/2 survey with positive serology were followed up 3 years after initial screening and assessed by means of (i) a clinical questionnaire, (ii) screening blood tests, and (iii) jejunal biopsy.
RESULTS: Forty-six subjects (21 male, mean age 51 years) have been followed up to date. Prior to follow-up, two of these subjects were diagnosed as having coeliac disease. Ten (3 male, mean age 51 years) of 44 subjects had enteropathy. Three of these 10 subjects were relatively asymptomatic, 3 had folate deficiency and 3 had iron deficiency. Thus 12 of the 1823 initially screened had enteropathy consistent with coeliac disease.
CONCLUSIONS: Coeliac disease is more prevalent than previous estimations and was found to be at least 1 in 152.