Alzheimer's & dementia (Amsterdam, Netherlands) · 2020
Impaired perfusion and capillary dysfunction in prodromal Alzheimer's disease.
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Nielsen Rune B, Parbo Peter, Ismail Rola, Dalby Rikke, Tietze Anna, Brændgaard Hans, Gottrup Hanne, Brooks David J, Østergaard Leif, Eskildsen Simon F
Аннотация
INTRODUCTION: Cardiovascular disease increases the risk of developing Alzheimer's disease (AD), and growing evidence suggests an involvement of cerebrovascular pathology in AD. Capillary dysfunction, a condition in which capillary flow disturbances rather than arterial blood supply limit brain oxygen extraction, could represent an overlooked vascular contributor to neurodegeneration. We examined whether cortical capillary transit-time heterogeneity (CTH), an index of capillary dysfunction, is elevated in amyloid-positive patients with mild cognitive impairment (prodromal AD [pAD]).
METHODS: We performed structural and perfusion weighted MRI in 22 pAD patients and 21 healthy controls.
RESULTS: We found hypoperfusion, reduced blood volume, and elevated CTH in the parietal and frontal cortices of pAD-patients compared to controls, while only the precuneus showed focal cortical atrophy.
DISCUSSION: We propose that microvascular flow disturbances antedate cortical atrophy and may limit local tissue oxygenation in pAD. We speculate that capillary dysfunction contributes to the development of neurodegeneration in AD.
METHODS: We performed structural and perfusion weighted MRI in 22 pAD patients and 21 healthy controls.
RESULTS: We found hypoperfusion, reduced blood volume, and elevated CTH in the parietal and frontal cortices of pAD-patients compared to controls, while only the precuneus showed focal cortical atrophy.
DISCUSSION: We propose that microvascular flow disturbances antedate cortical atrophy and may limit local tissue oxygenation in pAD. We speculate that capillary dysfunction contributes to the development of neurodegeneration in AD.