Isolated Langerhans cell histiocytosis of the stomach: a case report and literature review.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by an abnormal proliferation of pathologic Langerhans cells. The clinical presentation of LCH is highly variable, ranging from a single-system limited disease, to severe, multi-organ diseases with high mortality. LCH usually affects children but very rarely involves adults. The most frequent sites for LCH are the bones, skin, lungs, pituitary gland, and lymph nodes. Gastrointestinal tract involvement by LCH is extremely rare, and only a few cases have been reported. We herein present anIsolated LCH of the stomach in adult. We have reviewed the histologic features and implications of this diagnosis.