Cancer cell · 2019
Pangenomic Classification of Pituitary Neuroendocrine Tumors.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Neou Mario, Villa Chiara, Armignacco Roberta, Jouinot Anne, Raffin-Sanson Marie-Laure, Septier Amandine, Letourneur Franck, Diry Ségolène, Diedisheim Marc, Izac Brigitte, Gaspar Cassandra, Perlemoine Karine, Verjus Victoria, Bernier Michèle, Boulin Anne, Emile Jean-François, Bertagna Xavier, Jaffrezic Florence, Laloe Denis, Baussart Bertrand, Bertherat Jérôme, Gaillard Stephan, Assié Guillaume
Аннотация
Pituitary neuroendocrine tumors (PitNETs) are common, with five main histological subtypes: lactotroph, somatotroph, and thyrotroph (POU1F1/PIT1 lineage); corticotroph (TBX19/TPIT lineage); and gonadotroph (NR5A1/SF1 lineage). We report a comprehensive pangenomic classification of PitNETs. PitNETs from POU1F1/PIT1 lineage showed an epigenetic signature of diffuse DNA hypomethylation, with transposable elements expression and chromosomal instability (except for GNAS-mutated somatotrophs). In TPIT lineage, corticotrophs were divided into three classes: the USP8-mutated with overt secretion, the USP8-wild-type with increased invasiveness and increased epithelial-mesenchymal transition, and the large silent tumors with gonadotroph transdifferentiation. Unexpected expression of gonadotroph markers was also found in GNAS-wild-type somatotrophs (SF1 expression), challenging the current definition of SF1/gonadotroph lineage. This classification improves our understanding and affects the clinical stratification of patients with PitNETs.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overCell LineageChromosome AberrationsDNA MethylationEndopeptidasesEndosomal Sorting Complexes Required for TransportEpigenesis, GeneticEpigenomeExomeFemaleHumansMaleMiddle AgedMutationNeoplasm InvasivenessNeuroendocrine TumorsPituitary GlandPituitary NeoplasmsPrognosisTranscriptomeUbiquitin ThiolesteraseYoung Adult