International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2008
Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Cavalcanti Ana L, Bagnoli Vicente R, Fonseca Angela M, Pastore Roberto A, Cardoso Eduardo B, Paixão Jucilene S, Soares José M, Saad Fabrício, Baracat Edmund C
Аннотация
OBJECTIVE: To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction.
METHOD: In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment.
RESULTS: Blood flow was significantly more improved in the sildenafil than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment.
CONCLUSION: Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.
METHOD: In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment.
RESULTS: Blood flow was significantly more improved in the sildenafil than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment.
CONCLUSION: Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.
Предметные рубрики MeSH
Blood Flow VelocityClitorisDouble-Blind MethodFemaleHumansMiddle AgedPersonal SatisfactionPiperazinesPostmenopausePurinesRegional Blood FlowSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalSildenafil CitrateSulfonesUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedVasodilator Agents