Biomarkers in medicine · 2026
Meta-analysis of the relationship between preoperative systemic immune inflammation index and prognosis of patients with biliary tract cancer.
СтатьяМетаанализОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liang Jiale, Wang Zepu, Lv Dan, Tuo Hongfang
Аннотация
OBJECTIVE: To evaluate the prognostic value of preoperative systemic immune-inflammation index (SII) for overall survival, recurrence-free survival, and clinicopathological features in patients with biliary tract cancer (BTC).
METHODS: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and major Chinese databases. Seventeen studies involving 4,965 patients were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HR) or odds ratios (OR) with 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Subgroup, sensitivity analyses, and funnel plots were conducted to explore heterogeneity and assess robustness.
RESULTS: High preoperative SII was significantly associated with worse overall survival (OS) (HR = 1.98, 95% CI = 1.76-2.23, p < 0.001) and recurrence-free survival (RFS) (HR = 1.57, 95% CI = 1.34-1.84, p < 0.001). It also correlated with a higher risk of lymph node metastasis (OR = 1.97, 95% CI = 1.52-2.55, p < 0.001), but showed no significant associations with vascular invasion, tumor differentiation, or perineural invasion.
CONCLUSION: Preoperative SII is an effective prognostic predictor for BTC, where elevated levels indicate poorer survival outcomes and increased likelihood of vascular and lymph node involvement.
METHODS: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and major Chinese databases. Seventeen studies involving 4,965 patients were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HR) or odds ratios (OR) with 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Subgroup, sensitivity analyses, and funnel plots were conducted to explore heterogeneity and assess robustness.
RESULTS: High preoperative SII was significantly associated with worse overall survival (OS) (HR = 1.98, 95% CI = 1.76-2.23, p < 0.001) and recurrence-free survival (RFS) (HR = 1.57, 95% CI = 1.34-1.84, p < 0.001). It also correlated with a higher risk of lymph node metastasis (OR = 1.97, 95% CI = 1.52-2.55, p < 0.001), but showed no significant associations with vascular invasion, tumor differentiation, or perineural invasion.
CONCLUSION: Preoperative SII is an effective prognostic predictor for BTC, where elevated levels indicate poorer survival outcomes and increased likelihood of vascular and lymph node involvement.