Clinical biochemistry · 2007
Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.
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Chatzikyriakidou Anthoula, Vakalis Konstantinos V, Kolaitis Nicholas, Kolios Georgios, Naka Katerina K, Michalis Lampros K, Georgiou Ioannis
Аннотация
OBJECTIVES: The role of SLC19A1 -43T>C, MTHFR 677C>T and MS 2756A>G polymorphisms on red cell and plasma folate levels.
DESIGN AND METHODS: Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease.
RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.
CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.
DESIGN AND METHODS: Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease.
RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.
CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.
Предметные рубрики MeSH
5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseBiomarkersCoronary Artery DiseaseErythrocytesFemaleFolic AcidFolic Acid DeficiencyGenetic Predisposition to DiseaseHumansMaleMembrane Transport ProteinsMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedPolymorphism, Single NucleotideReduced Folate Carrier ProteinSerum