Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.

OBJECTIVES

The role of SLC19A1 -43T>C, MTHFR 677C>T and MS 2756A>G polymorphisms on red cell and plasma folate levels.

DESIGN AND

METHODS

Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease.

RESULTS

The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.

CONCLUSION

SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.