The effect of antihypertensive treatment on the incidence of stroke and cognitive decline in the elderly: a meta-analysis.

AIM: To evaluate the effectiveness of antihypertensives in reducing neurocognitive outcomes in elderly patients.

PATIENTS &

METHODS

We conducted a systematic literature search of randomized trials in which hypertensive patients with a mean age ≥65 years received antihypertensive or control treatment. Outcomes were stroke, transient ischemic attack, cognitive decline and dementia. We included 14 trials for meta-analysis.

RESULTS

Compared to placebo, antihypertensive treatment reduced the risk of stroke (RR: 0.67 [95% CI: 0.57-0.79]). Reduced risk was significant for transient ischemic attack, fatal stroke, nonfatal stroke and total stroke. There were insufficient data to compare individual agents.

CONCLUSION

Antihypertensive treatment is associated with a significant reduction in stroke in elderly individuals. Reductions in dementia and cognitive decline were not significant; however, there was short follow-up. Comparative effectiveness evidence is limited.