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Аннотация
AIM: To identify the expression of proteins in cardiomyocytes in rats with left kidney artery coarctation.
METHODS
16 male SD rats were separated into 2 groups (n=8): 2 kidney 1 Clip group (2K1C) and sham operation group (SO). The postoperational 8th week, after examination by normal doppler and tissue doppler echocardiography, the extracted proteins from cardiomyocytes were isolated by two-dimensional gel electrophoresis with staining. The gel images were acquired by scanner and 2-DE analysis software. Different spots observed on two 2D gels were selected and identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
RESULTS
Overall, 21 protein spots showed significant difference, and 14 out of which were identified.
CONCLUSION
Kidney artery coactation-induced cardiac hypertrophy displays different expression of proteins in cardiomyocytes.
Предметные рубрики MeSH
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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