Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis.

SYSTEMATIC REVIEW

CONCLUSION

Preliminary evidence suggests scaling and root planing (SRP) in combination with amoxicillin (AMX)/metronidazole (MET)(SRP + AMX/MET) therapy may be more effective in treating chronic periodontitis(CP) than is SRP alone. CRITICAL SUMMARY ASSESSMENT: Preliminary evidence from a meta-analysis of four randomized clinical trials (RCTs) seems to support the effectiveness of systemic AMX/MET therapy as an adjunct to SRP alone in treating CP, although safety data are incomplete. EVIDENCE QUALITY RATING: Limited.