Effectiveness of Emdogain in the periodontal treatment.

OBJECTIVES

The study was designed to investigate how the periodontal disease treatment with Emdogain may influence the parameters of serum acute phase response and the total antioxidant status (TAS) of nonstimulated saliva.

MATERIAL AND

METHODS

The wound healing process after periodontal treatment provided with EMD and regular open flap procedure was observed in 28 patients. TAS in saliva and acute phase proteins in blood was measured before and after treatment.

RESULTS

The PD varied from 3,91 mm before treatment to 1,27 after it in EMD group and from 3,83 mm and 1,33 in the control group. CAL varied from 3,2 - 2,4 mm in EMD group and from 2,70 - 2,2 in the control group (p<0,01 and p<0,001). On the basis and after treatment of acute phase proteins analysis existence of chronic inflammatory state with slight decreased total concentration of AGP, ACP. Low TAS level found in the saliva of the subjects in our study may suggest that the antioxidant defence of saliva in patients with chronic periodontitis is poor.