Shanghai kou qiang yi xue = Shanghai journal of stomatology · 2012
[Association of variants in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population].
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Chen Dong, Wei Ning, Bao Xiao-ni, Wang Li-ming, Zhou Chun-fei, Zhang Yu-ling, Zhang Jie
Аннотация
PURPOSE: To investigate the association of the single nucleotide polymorphism (SNP) in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population.
METHODS: rs2891168,rs1333048 and rs1333042 genotypes of randomly grouped 172 healthy control subjects and 221 patients with chronic periodontitis(CP) were genotyped by TaqMan probe real-time fluorescent quantitative PCR. Statistical analysis of Chi-square test was performed using SPSS16.0 software package.
RESULTS: Rs2891168 was closely associated with chronic periodontitis(P=0.003), and the frequency of G allele was higher in the patients compared with the control(48.36% vs 40.00%, OR=1.209, 95% CI: 1.001-1.461, P=0.045). Rs1333048 and rs1333042 were not associated with chronic periodontitis.
CONCLUSIONS: There is SNP correlated with chronic periodontitis in chromosome 9p21.3, which indicates that the 9p21.3 locus may be the susceptible region. However, the mechanism remains unclear.
METHODS: rs2891168,rs1333048 and rs1333042 genotypes of randomly grouped 172 healthy control subjects and 221 patients with chronic periodontitis(CP) were genotyped by TaqMan probe real-time fluorescent quantitative PCR. Statistical analysis of Chi-square test was performed using SPSS16.0 software package.
RESULTS: Rs2891168 was closely associated with chronic periodontitis(P=0.003), and the frequency of G allele was higher in the patients compared with the control(48.36% vs 40.00%, OR=1.209, 95% CI: 1.001-1.461, P=0.045). Rs1333048 and rs1333042 were not associated with chronic periodontitis.
CONCLUSIONS: There is SNP correlated with chronic periodontitis in chromosome 9p21.3, which indicates that the 9p21.3 locus may be the susceptible region. However, the mechanism remains unclear.