[Association of variants in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population].

PURPOSE: To investigate the association of the single nucleotide polymorphism (SNP) in chromosome 9p21.3 and chronic periodontitis in the Han Chinese population.

METHODS

rs2891168,rs1333048 and rs1333042 genotypes of randomly grouped 172 healthy control subjects and 221 patients with chronic periodontitis(CP) were genotyped by TaqMan probe real-time fluorescent quantitative PCR. Statistical analysis of Chi-square test was performed using SPSS16.0 software package.

RESULTS

Rs2891168 was closely associated with chronic periodontitis(P=0.003), and the frequency of G allele was higher in the patients compared with the control(48.36% vs 40.00%, OR=1.209, 95% CI: 1.001-1.461, P=0.045). Rs1333048 and rs1333042 were not associated with chronic periodontitis.

CONCLUSIONS

There is SNP correlated with chronic periodontitis in chromosome 9p21.3, which indicates that the 9p21.3 locus may be the susceptible region. However, the mechanism remains unclear.