[Activity of blood platelets and functional state of endothelium in patients with unstable angina with favorable and unfavorable outcome (prospective study)].

Functional activity of platelets (aggregation and plasma levels of soluble P-selectin) and functional state of endothelium (antiaggregatory activity of vessel wall - AAVW, cuff occasion test, and plasma content of von Willebrand factor) were assessed in patients with unstable (n=41) and stable (n=19) angina and healthy donors (n=20). According to results of follow up for 1 year patients with unstable angina (UA) were divided into 2 groups - with (n=21) and without (n=20) events (coronary death, nonfatal myocardial infarction). In patients with UA and events parameters of spontaneous and ADP-induced platelet aggregation, contents of P-selectin and von Willebrand factor were higher while AAVW lower than in UA patients without events, patients with stable angina and healthy subjects. Correlations between AAVW and platelet aggregation, between AAVW and level of von Willebrand factor were negative in patients with UA, and positive in patients with stable angina and healthy subjects. These results of correlation analysis were interpreted as a reflection of impairment of antithrombotic endothelial function in patients with UA.