Pharmacotherapy · 2002
Comparison of two needle sizes for subcutaneous administration of enoxaparin: effects on size of hematomas and pain on injection.
Клиническое исследованиеСравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Robb Dawn M, Kanji Zahra
Аннотация
STUDY OBJECTIVE: To determine whether use of a smaller needle size for subcutaneous injection of enoxaparin would reduce the size of injection-site hematomas and/or decrease the pain of injection.
DESIGN: Prospective, randomized trial.
SETTING: Community hospital in North Vancouver, British Columbia, Canada.
PATIENTS: One hundred twenty-four patients with unstable angina or non-Q-wave myocardial infarction who were administered enoxaparin for anticoagulation.
INTERVENTION: Each patient was randomly assigned to one of two groups. One group received enoxaparin injections with a 30-gauge, 5/16-inch insulin syringe, and the other group was injected with a 26-gauge, 3/8-inch tuberculin syringe.
MEASUREMENTS AND MAIN RESULTS: Participating nurses used standard measuring tape to determine the largest diameter of each hematoma. Pain was assessed with a 10-unit numeric scale. The two groups did not differ significantly with regard to either the mean size of the largest hematoma/patient (4.2 cm in the insulin-syringe group vs 3.8 cm in the tuberculin-syringe group, p=0.68) or the mean pain score (0.3 in the insulin-syringe group vs 0.5 in the tuberculin-syringe group, p=0.10).
CONCLUSIONS: Use of a 30-gauge, 5/16-inch insulin syringe instead of a 26-gauge, 3/8-inch tuberculin syringe does not significantly reduce either hematoma size or pain of injection. A larger study is required to determine whether needle size affects the frequency of hematoma formation.
DESIGN: Prospective, randomized trial.
SETTING: Community hospital in North Vancouver, British Columbia, Canada.
PATIENTS: One hundred twenty-four patients with unstable angina or non-Q-wave myocardial infarction who were administered enoxaparin for anticoagulation.
INTERVENTION: Each patient was randomly assigned to one of two groups. One group received enoxaparin injections with a 30-gauge, 5/16-inch insulin syringe, and the other group was injected with a 26-gauge, 3/8-inch tuberculin syringe.
MEASUREMENTS AND MAIN RESULTS: Participating nurses used standard measuring tape to determine the largest diameter of each hematoma. Pain was assessed with a 10-unit numeric scale. The two groups did not differ significantly with regard to either the mean size of the largest hematoma/patient (4.2 cm in the insulin-syringe group vs 3.8 cm in the tuberculin-syringe group, p=0.68) or the mean pain score (0.3 in the insulin-syringe group vs 0.5 in the tuberculin-syringe group, p=0.10).
CONCLUSIONS: Use of a 30-gauge, 5/16-inch insulin syringe instead of a 26-gauge, 3/8-inch tuberculin syringe does not significantly reduce either hematoma size or pain of injection. A larger study is required to determine whether needle size affects the frequency of hematoma formation.