Bisoprolol improved endothelial function and myocardium survival of hypertension with stable angina: a randomized double-blinded trial.

AIM: This study was designed to determine the effect of bisoprolol on endothelial function of brachial artery and the myocardium survival in hypertensive patients with stable angina.

PATIENTS AND

METHODS

222 subjects with hypertension who had received coronary angiography examination were involved in the study, 162 in bisoprolol therapy group (96 men, 59%) and 60 in non-bisoprolol group (39 men, 65%). In accordance with results of angiography (coronary stenosis ≥ 50%), the patients in bisoprolol group were divided into three sub-groups: (1) single-vessel coronary disease group (n=42); (2) double-vessel coronary disease group (n=44); (3) multi-vessel coronary disease group (n=39) and hypertension-only group (n=37). All the subjects were treated with conventional drugs plus bisoprolol and followed up for 12 months. Parameters of clinical features, echocardiography, radionuclide ventriculographic and laboratory findings were measured and analyzed.

RESULTS

After 12 months bisoprolol treatment, the flow-mediated vasodilatation (FMD) and 99Tcm-sestamibi (99Tcm-MIBI) uptake fraction which reflects the survival of myocardium were improved markedly in bisoprolol group (all p < 0.05). Interestingly, a more significant improvement in FMD and 99Tcm-MIBI uptake fraction were observed in severe coronary disease sub-groups (double-vessel group and multi-vessel group) when compared with single-vessel sub-group (p < 0.05).

CONCLUSIONS

Hypertensive subjects with stable angina might get benefit from the treatment of bisoprolol in improving endothelial function and the survival of myocardium.