The journal of medical investigation : JMI · 2021
The effects of androgens on metabolic functions in females.
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Iwasa Takeshi, Yamamoto Yuri, Shinya Akari, Minato Saki, Yanagihara Rie, Kamada Shuhei, Imaizumi Junki, Kagawa Tomohiro, Shirakawa Aya, Noguchi Hiroki, Nakagawa Tomotaka, Taniguchi Miyu, Kadota Yuri, Kawakita Takako, Yoshida Kanako, Kato Takeshi, Yasui Toshiyuki, Irahara Minoru
Аннотация
The metabolic effects of androgens and their underlying mechanisms in females have been revealed by recent studies. An excess of androgens can have adverse effects on feeding behavior and metabolic functions and induce metabolic disorders / diseases, such as obesity, insulin resistance, and diabetes, in women and experimental animals of reproductive age. Interestingly, these effects of androgens are not observed in ovariectomized animals, indicating that their effects might be dependent on the estrogen milieu. Central and peripheral mechanisms, such as alterations in the activity of hypothalamic factors, reductions in energy expenditure, skeletal muscle insulin resistance, and β-cell dysfunction, might be related to these androgens' effects. J. Med. Invest. 68 : 228-231, August, 2021.