[A case of Vogt-Koyanagi-Harada syndrome-like lesions during pucotenlimab treatment for malignant melanoma].

A patient presented to the ophthalmology department with bilateral blurred vision, with a history of intravenous infusion of Pucotenlimab injection for malignant melanoma. Examinations revealed right anterior chamber inflammation, bilateral papilledema and macular edema. Optical Coherence Tomography (OCT) showed choroidal elevation in the macular area of both eyes, accompanied by multifocal exudative neurosensory detachment and pigment epithelial detachment. Indocyanine Green Angiography (ICG-A) demonstrated multifocal patchy hyperfluorescence in the posterior pole of both eyes in the early phase, weak fluorescence of horizontal choroidal folds, and hyperfluorescence in the posterior pole in the late phase. Based on the medical history, the patient was diagnosed with bilateral drug-related Vogt-Koyanagi-Harada (VKH) syndrome-like lesions. Treatment with intravitreal injection of dexamethasone sustained-release implant in the right eye combined with systemic glucocorticoid therapy resulted in improvement of ocular symptoms.