Cutaneous Manifestations of Epstein-Barr Virus: A Unique Case of Gianotti-Crosti Syndrome.

Epstein-Barr virus (EBV) plays a role in the pathogenesis of a wide variety of acute and chronic diseases. Cutaneous manifestations of EBV include exanthems, chronic infections, malignancies, and small vessel vasculitides. Clinically and histologically, many of these conditions can imitate each other, making diagnosis challenging. In this report, we present a case of a child who developed Gianotti-Crosti syndrome with histopathologic features of anti-neutrophil cytoplasmic antibody (ANCA) vasculitis in the setting of acute EBV infection. Furthermore, we review the literature on EBV-induced cutaneous small vessel vasculitis and discuss pathogenic mechanisms.