Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation.
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Qian Frank, Tintle Nathan, Jensen Paul N, Lemaitre Rozenn N, Imamura Fumiaki, Feldreich Tobias Rudholm, Nomura Sarah Oppeneer, Guan Weihua, Laguzzi Federica, Kim Eunjung, Virtanen Jyrki K, Steur Marinka, Bork Christian S, Hirakawa Yoichiro, O'Donoghue Michelle L, Sala-Vila Aleix, Ardisson Korat Andres V, Sun Qi, Rimm Eric B, Psaty Bruce M, Heckbert Susan R, Forouhi Nita G, Wareham Nicholas J, Marklund Matti, Risérus Ulf, Lind Lars, Ärnlöv Johan, Garg Parveen, Tsai Michael Y, Pankow James, Misialek Jeffrey R, Gigante Bruna, Leander Karin, Pester Julie A, Albert Christine M, Kavousi Maryam, Ikram Arfan, Voortman Trudy, Schmidt Erik B, Ninomiya Toshiharu, Morrow David A, Bayés-Genís Antoni, O'Keefe James H, Ong Kwok Leung, Wu Jason H Y, Mozaffarian Dariush, Harris William S, Siscovick David S, Fatty Acids and Outcomes Research Consortium (FORCE)
Аннотация
OBJECTIVES: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF.
METHODS: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis.
RESULTS: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively.
CONCLUSIONS: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.