Journal of assisted reproduction and genetics · 2007
The possible role of hyperhomocysteinemia on IVF outcome.
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Pacchiarotti Arianna, Mohamed Mohamed A, Micara Giulietta, Linari Antonella, Tranquilli Daniela, Espinola Salomè B, Aragona Cesare
Аннотация
PURPOSE: To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.
METHOD: Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.
RESULTS: Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.
CONCLUSION: The results suggest that hyperhomocysteinemia could affect IVF outcome.
METHOD: Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.
RESULTS: Pregnancy rate, implantation rate and abortion rate varied significantly (p<or=0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups.
CONCLUSION: The results suggest that hyperhomocysteinemia could affect IVF outcome.