Fine particulate air pollution and occurrence of spontaneous intracerebral hemorrhage in an area of low air pollution.

OBJECTIVES

The association between short-term ambient particulate matter ≤ 2.5 μm diameter (PM2.5) and spontaneous intracerebral hemorrhage (SICH) occurrence is unclear. We aimed to study the association of ambient PM2.5 with occurrence of SICH in an area of low air pollution in southern Portugal.

PATIENTS AND

METHODS

PM2.5 levels from the 3 days before the SICH event (Lag 1, 2, 3) was compared with one control period (Lag 15-17) using a case-crossover analysis. Conditional logistic regression was used to estimate the odds ratio (OR) with 95% confidence interval (CI). Analysis was stratified by gender, age, functional neurological status, type of SICH, environmental factors (temperature, humidity, time of day and season).

RESULTS

Three-hundred and eight patients were included (2010-2015); mean age 70.8 years, 62.8% were males. The mean values (μg/l) of PM2.5 were higher on the case days (Lag1 = 7.76, Lag2 = 7.64, Lag3 = 7.74) compared to control period (Lag14-17 = 6.77). For each 10 μg/l increase, the likelihood of SICH increased 5.7% (95% CI = 1.020-1.095. P = .002). The strength of the association was higher in patients younger than 70 years (OR = 1.064, 95% CI = 1.009-1.122); without prior to SICH neurological disability (OR = 1.061, 95% CI 1.022-1.101); with non-lobar type (OR = 1.054, 95% CI = 1.012-1.099). A circadian and circannual pattern was present with increased strength of the association when SICH occurred in the morning time (OR = 1,067, 95% CI = 1.012-1.125), in the fall (OR = 1.118, 95% CI = 1.031-1.213) and the in the winter (OR = 1.064, 95% CI = 1.002-1.129). The association was also potentiated at lower temperature values.

CONCLUSION

Short-term increases of PM2.5 are associated with occurrence of SICH in Algarve, a region of low ambient pollution. Patient and ambient level factors can influence the strength of this association.