[Morphological changes and function of gastric and pancreatic mucosa after selective proximal vagotomy in patients with pyloroduodenal ulcer].

The pathomorphological changes in the gastric mucosa and acid production were studied in 118 patients with ulcer disease of a pyloric portion of the stomach and duodenum before and after selective proximal vagotomy in combination with drainage operation. Before the operation, the atrophic changes were the most pronounced in the gastric antrum. Increase in debit of chlorohydric acid was caused by increase in the volume of gastric juice and acid production. Stimulation with food contributes to considerable increase in gastrin concentration in the blood of the patients in low level of glucagon and insulin. Early after the operation, the signs of acute inflammation were revealed in the mucosa of the body and antrum. In increase of a basal level of gastrin and glucagon, acid production significantly decreased. Long-term atrophic gastritis of the body of a stomach was noted mainly in patients with delayed evacuation of its contents. Normalization of the level of hormones correlated with the indices of acid-producing function of the stomach.